Literature

Literature and Studies on Microneedling

Microneedling causes a notable increase of elastic fibres in the treated skin area and the skin thickness increases.
Schwarz M, Laaff H. (2011) A prospective controlled assessment of microneedling with the Dermaroller device.
Plast
 Reconstr Surg. Jun;127(6):146e-8e.

The collagen induction, which is caused by microneedling, provides very good results in the treatment of wrinkles, scars, acne scars and stretch marks.
Furthermore burn scars and hypo
 pigmented scars adapt to the surrounding skin area due to revascularization and repigmentation.
Fernandes D. (2005) Minimally invasive percutaneous collagen induction. Oral Maxillofac Surg Clin North Am. Feb;17(1):51-63, vi.
Fernandes D. (2002) Percutaneous collagen induction: an alternative to laser resurfacing. Aesthet Surg J. May;22(3):307-9.

A notable increase of collagen and elastin was proven six month after the microneedling treatment.
Compared with the scar tissues, the collagen in the treated area was cross-linked and the stratum corneum was structured normally.
Furthermore a thickening of the epidermis of about 40% was
 observed.
Aust MC, Fernandes D, Kolokythas P, Kaplan HM, Vogt PM. (2008) Percutaneous collagen induction therapy: an alternative
treatment for scars, wrinkles, and skin laxity. Plast Reconstr Surg. Apr;121(4):1421-9.

Due to the low risk of post inflammatory hyperpigmentation compared to other methods (e.g.: laser, chemical peeling, …), microneedling can be used for all patients, independent from skin type and skin colour.
Fabbrocini G, Annunziata MC, D’Arco V, De Vita V, Lodi G, Mauriello MC, Pastore F, Monfrecola G. (2010)
Acne scars: 
pathogenesis, classification and treatment. Dermatol Res Pract. 2010:893080. Epub 2010 Oct 14.

Microneedling forces a gene expression of numerous growth factors (TGF-β3, VEGF, EGF, FGF,…), collagen I and glycosaminoglycan.
Compared with TGF- β1 and TGF- β2, TFG- β3 is regulated high
 beyond the initial phase, which supports scar less healing and a normal collagen structure.
Aust MC, Reimers K, Gohritz A, Jahn S, Stahl F, Repenning C, Scheper T, Altintas MA, Schwaiger N, Redeker J, Vogt PM (2010)
Percutaneous collagen induction. Scarless skin rejuvenation: fact or fiction? Clinical and Experimental Dermatology, 35, 437–439.
Aust MC, Reimers K, Repenning C, Stahl F, Jahn S, Guggenheim M, Schwaiger N, Gohritz A, Vogt PM. (2010) Percutaneous
collagen induction: minimally invasive skin rejuvenation without risk of hyperpigmentation-fact or fiction?
Plast Reconstr 
Surg. 2008 Nov;122(5):1553-63.

The micro pores which are created during microneedling (without occlusion) will be closed about 10-15 minutes after the treatment.
Whereby the risk of a following infection is very low.

Bal S, Kruithof AC, Liebl H, Tomerius M, Bouwstra JA, Lademann J, Meinke M. (2010a) In vivo visualization of microneedle
conduits in human skin using laser scanning microscopy.Laser Physics Letters. 7(3):242-247.
Bal SM, Kruithof AC, Zwier R, Dietz E, Bouwstra JA, Lademann J, Meinke MC. (2010b) Influence of microneedle shape on the
transport of a fluorescent dye into human skin in vivo. J Control Release. Oct 15;147(2):218-24. Epub 2010 Jul 25.